A high level of adherence to the antiretroviral therapy is needed to obtain optimal long-term benefits. To further understand predictors of adherence to the antiretroviral therapy, we assessed level of adherence and explored possible factors associated with no adherence in a population of the lowincome suburbs of Buenos Aires. A cross-sectional study was conducted in HIV-infected adults on antiretroviral therapy. Participants answered a validated questionnaire assessing sociocognitive and sociodemographic variables. Adherence was assessed asking number of missed doses for the last four days prior to the visit. Chi squared or Fisher´s exact test for nominal data and Student´s t test for continuous variables were used to assess statistically significant differences. 71 patients participated in the study; women 41 (58%) mean age: 35.3; men 30 (42%) mean age 40.4. Fifty (70.4%) reported adherence > 95%. HIV-1 RNA levels were < 500 copies/ml in 80.4% of the adherent group and in 34% of the non adherent. Feeling frequently or always sad, without motivation and/or depressed the week prior to the interview was associated with adherence < 95% in the bivariate analysis Age, gender, education level, employment status, HIV risk factors, alcohol use, drug use, presence of symptoms, self-efficacy, the belief of a link between non-adherence and resistance, social and family support, pill burden and receive a PI containing regimen were not associated with adherence level.
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Authors: Eduardo Warley, David Shield, Mónica Salas, Inés Vieni, Silvia Monetti, Marcela Belforte, Sarah MacCarthy, Javier Desse, Silvia Cetani, Edgardo Szyld, Alejandra Gurtman, Debbie Indyk
Published By: Revista Panamericana de Infectologia
Year: May 9, 2008
Publication Link: http://www.revistaapi.com/wp-content/uploads/2014/03/mat-071.pdf