Addressing Mpox, declared a public health emergency in July 2022, requires not only strong political commitment grounded in sound evidence and science, but explicit attention to human rights and the voices of affected communities. For our first lecture of the 2023 spring semester, on Jan. 19, IIGH partnered with the UCLA Center for Global and Immigrant Health to convene an esteemed panel of researchers, scholars, scientists and practitioners for a discussion on lessons learned from HIV, COVID-19, Ebola and mpox in developing, implementing and monitoring responses to public health emergencies, with attention to understanding and approaching structural inequalities and their role in epidemics moving forward.